Fibrous Dysplasia of Bone in Male Patients with Precocious Puberty and Elevated Serum Testosterone

This protocol applies to male patients with fibrous dysplasia of bone who present with precocious puberty alongside elevated serum testosterone and/or advanced bone age — a specific hormonal picture that requires directed treatment beyond bone disease management alone.

Treatment for precocious puberty is indicated when it is associated with elevated serum testosterone and/or bone age advancement. The presence of these findings in the context of fibrous dysplasia of bone signals the need for active hormonal intervention.

Management involves a combination of a testosterone receptor blocker and an aromatase inhibitor. The full protocol — including agent selection, monitoring requirements, and criteria for escalation — is available in the complete structured regimen.