When initial surgical resection for localized, non-high-grade fibrosarcoma (histological grade G1 or GX) fails to yield histologically tumour-free margins, a defined clinical next step applies. This page describes that scenario and points to the full structured protocol.
Localized fibrosarcoma with non-high-grade histology (G1 or GX). Surgery represents the standard therapy for localized soft tissue sarcomas, with complete tumour-free resection as the primary goal.
The initial approach — wide surgical resection or compartment resection, with a recommended safety margin of 2 cm — did not achieve histologically tumour-free (R0) resection margins. Failure to reach R0 is the condition that triggers escalation to this next clinical step.
A further surgical intervention may be considered in this R1/R2 setting. The complete criteria, options, and clinical sequencing are detailed in the full protocol.
Histological tumour-free resection margins (R0) — to minimise the risk of local recurrence.
DOI: 10.18632/oncotarget.20136