What Is the Treatment of Fibrosarcoma in Advanced Stage or Metastatic Disease?
Clinical Scenario
This protocol addresses patients with advanced stage or metastatic fibrosarcoma — a presentation requiring systemic treatment as the primary therapeutic strategy.
First-Line Treatment Approach
Chemotherapy for advanced or metastatic fibrosarcoma is built around anthracycline-based regimens as the established first-line framework. Additional single-agent and combination options exist within this setting.
Full agent selection, combination criteria, and sequencing are available in the complete protocol below.
References
DOI: 10.18632/oncotarget.20136
- Chemotherapy in patients with advanced stage fibrosarcomas is based on anthracyclines as the first-line treatment.
- In this context, doxorubicin is the most widely applied drug.
- Besides doxorubicin, response rates above 15% can be reached by actinomycin D and ifosfamide.
- Due to the positive results of the phase II trial, the combination of olaratumab and doxorubicin has been approved in the United States as a first-line therapy for patients with advanced soft-tissue sarcoma responding to anthracycline therapy.
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