Fascioliasis is a parasitic helminth infection requiring targeted antiparasitic treatment to achieve confirmed clearance. The first-line protocol specifies the drug, how it should be taken, and the follow-up criteria used to verify success.

Treatment Approach

First-line management centres on an antiparasitic agent — triclabendazole — administered together with high-fat food to optimise absorption. The complete dosing schedule and regimen details are available in the full protocol.

Full dosing, timing, and algorithm in the structured regimen below.

Treatment Goals

The primary endpoint is negative microscopy for Fasciola infection, assessed at 10–15 days after treatment and repeated at 30 days. Persistent positivity can be further evaluated by ultrasound.

References

In case of therapeutic failure (when the medication does not produce the desired effect) or if the medical professional in charge of the patient considers it necessary, two doses of 10 mg/kg can be given every 12–24 hours for a total dose of 20 mg/kg.
To evaluate the effectiveness of treatment in individual cases, it is suggested to use microscopy 10–15 days after the treatment, and repeat it after 30 days.
If the patient remains positive, this can be confirmed by ultrasound after 30–35 days.

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Treatment of Fascioliasis: First-Line Antiparasitic Protocol

References