Treatment of Familial Mediterranean Fever Presenting with Exertional Leg Pain

Clinical Scenario

This protocol applies to FMF patients who experience exertional leg pain — leg pain that occurs during or following physical activity. This symptom pattern has dedicated management recommendations within the broader FMF evidence base.

Treatment Approach

Guidelines suggest a role for a specific class of anti-inflammatory agents in managing this presentation. The complete regimen — including agent selection, dosing, and any additional considerations — is detailed in the full structured protocol.

The full evidence-based algorithm, including dosing and sequence, is available via the protocol below.