Ewing's sarcoma arising from a non-sacral pelvic site poses distinct local-control challenges. The pelvic primary location has direct implications for surgical planning, radiation therapy, and consolidation strategy.
This protocol addresses Ewing's sarcoma in which the primary tumour is located in the pelvis, excluding the sacrum. Adjuvant radiotherapy is a key local-control consideration in this setting, irrespective of surgical margins, tumour volume, or histological response to prior treatment.
For a selected subgroup of patients who achieve complete remission, consolidation with high-dose chemotherapy represents one component of the management pathway — full eligibility criteria, sequencing, and regimen details are set out in the complete protocol.
DOI: 10.1016/j.annonc.2021.08.1995
Also, adjuvant RT should be considered in patients with non-sacral pelvic ES regardless of surgical margins, tumour volume or histological response, as this was shown to have superior local control and survival outcomes compared with surgery alone [II, B].
For selected patients with a long disease-free interval of ≥2 years achieving a complete remission through medical therapy and/or surgery, consolidation with high-dose ChT may be considered [V, C].
View source ↗