Treatment of Locally Advanced Resectable Oesophageal Squamous-Cell Carcinoma (cT2–T4a or cN1–3, M0)

Clinical Scenario

This protocol addresses oesophageal squamous-cell carcinoma (SCC) that is locally advanced but remains surgically resectable — staged cT2 to T4a, or with regional lymph node involvement (cN1–3), without distant metastasis (M0). It covers first-line curative-intent management for this population.

Condition

Surgery remains the backbone of curative-intent treatment for locally advanced resectable oesophageal SCC (cT2–T4a or cN1–3). Definitive chemoradiotherapy with close surveillance and salvage oesophagectomy when needed is also a recommended option, even in upfront resectable cases.

Treatment Approach

Management involves chemoradiotherapy-based strategies combined with a surgical approach. The full protocol specifies regimens, sequencing, and all clinical parameters.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1016/j.annonc.2022.07.003

Surgery is still the backbone of curative-intent treatment for both histological subtypes of locally advanced resectable oesophageal cancer (cT2-T4a or cN1-3), although definitive CRT with surveillance and salvage oesophagectomy when needed for local tumour control is also a recommended option, even in upfront resectable cases of oesophageal SCC.
Locally advanced oesophageal SCC should be treated with CRT followed by surgery [I, A] or definitive CRT with close surveillance and salvage surgery for local tumour persistence or progression [II, B].

View source ↗