El período posparto es un período de elevado riesgo trombótico. En mujeres con deficiencia de Proteína C que también presentan antecedentes familiares de primer grado de tromboembolismo venoso (TEV), este riesgo adquiere una relevancia clínica adicional y requiere una respuesta de manejo estructurada.
Escenario ClínicoLa guía basada en evidencia respalda la tromboprofilaxis posparto en este contexto. El régimen estructurado completo — incluida la intervención específica, el momento de inicio y la duración — se detalla en el protocolo completo.
For women with a first-degree family history of VTE and known homozygous FVL, a combination of FVL and PGM, antithrombin deficiency, protein C deficiency, or protein S deficiency in the family, the ASH guideline panel suggests testing for the known familial thrombophilia.
The panel determined that on balance, with small effects (preventing VTE in the postpartum period) and trivial undesirable effects (more major bleeding) for women with a sibling with homozygous FVL and women with a first-degree family history of a combination of FVL and PGM, or antithrombin, protein C, or protein S deficiency, a strategy of testing for thrombophilia and thromboprophylaxis postpartum in women with thrombophilia would probably be favored.
Thromboprophylaxis postpartum continues until 6 weeks after delivery.
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