Este protocolo aborda la trombocitemia esencial en la categoría de riesgo intermedio: pacientes mayores de 60 años que son JAK2 tipo salvaje, sin eventos trombóticos previos y sin factores de riesgo cardiovascular.
El objetivo primario en este contexto es el alivio de los trastornos vasomotores (microvasculares) asociados a la trombocitemia esencial.
DOI: 10.1002/ajh.27216
Figure 5 outlines our general treatment approach in ET, which starts with thrombosis risk stratification: very low (age ≤60 years, no thrombosis history, JAK2 wild-type), low (same as very low but JAK2 mutation present), intermediate (age >60 years, no thrombosis history, JAK2 wild-type), and high (thrombosis history present or age >60 years with JAK2 mutation).
Twice-daily aspirin is also our current treatment choice for intermediate-risk disease, but combination of a cytoreductive drug with once-daily aspirin is a reasonable alternative in intermediate-risk patients with CV risk factors (Figure 5).
Low-dose aspirin therapy has also been shown to be effective in alleviating vasomotor (microvascular) disturbances associated with ET or PV.
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