Treatment of Recurrent Erythema Multiforme — HSV-Associated or Idiopathic

This protocol applies to patients experiencing recurrent erythema multiforme — whether episodes are triggered by HSV infection or arise without an identifiable infectious cause (idiopathic). Managing the recurrent pattern, rather than individual acute episodes, is the clinical focus.

In both HSV-associated and idiopathic recurrent erythema multiforme, antiviral prophylaxis is the established first-line approach. When recurrences remain severe despite this, the case escalates to a more intensive management strategy.

In severe recurrent erythema multiforme major where antiviral prophylaxis and subsequent systemic therapy have not achieved adequate disease control, a targeted biological agent has demonstrated benefit in this refractory setting.

The complete structured regimen — including agent selection, criteria for use, and step-by-step management — is available via the link below.