Treatment of Epilepsy with Myoclonic Atonic Seizures in Stormy Phase with Generalised Tonic-Clonic Seizures

In epilepsy with myoclonic atonic seizures, a subset of patients enters a distinct, high-burden period known as the stormy phase — characterised by numerous seizures of multiple types occurring together, including generalised tonic-clonic and myoclonic seizures.

Clinical Scenario

This protocol addresses management during this acute presentation, where generalised tonic-clonic and myoclonic seizures are both active and seizure control has not been achieved with other measures.

Treatment Approach & Goals

The primary clinical goal is control of generalised convulsive seizures. The approach in this scenario involves a specific anticonvulsant for seizures that have proven resistant to other medications — the full regimen, including selection criteria and sequencing, is detailed in the complete protocol.