Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare and severe epileptic syndrome with onset in the first months of life. It is characterised by focal seizures that migrate from one cortical region to another, marked pharmacoresistance, and severe long-term cognitive disability. Affected infants typically present with multiple daily seizures that persist despite sequential drug trials.
Management involves antiepileptic drug (AED) therapy. Given the defining pharmacoresistance of this syndrome, treatment requires careful selection and sequencing of agents. The complete structured regimen — including specific drug choices, sequencing, and decision points — is in the full protocol.
DOI: 10.1212/NXG.0000000000000363
Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare and severe epileptic syndrome characterized by (1) seizure onset during the first months of life, (2) focal seizures migrating from one cortical region to another, (3) marked pharmacoresistance, and (4) severe cognitive long-term disability.
All patients had multiple daily seizures at the onset and continued to have frequent seizures, resistant to 3 or more AED trials in the first month to the first year of life.
View source ↗