Focal (Partial) Seizures in Adults Aged 60 and Older: What Is the Treatment?

Managing epilepsy in older adults presents a distinct clinical picture. When seizures arise from a focal onset in patients aged 60 and older, the treatment approach must account for the specific characteristics of this population.

Clinical Scenario

This protocol applies to adults aged 60 years and older who experience focal (partial) seizures — seizures originating within networks limited to one hemisphere, which may present with subjective (aura), motor, autonomic, or dyscognitive features.

Treatment Approach

When initial monotherapy has not achieved seizure control, the structured evidence-based approach for this population involves combination therapy with more than one antiepileptic drug.

The full regimen — including which agents, sequencing, and monitoring considerations — is available in the complete protocol.

Instant Access to Structured Evidence-Based Regimens

References

Seizure originating within networks limited to one hemisphere characterized by subjective (aura), motor, autonomic, and dyscognitive features
Older adults (60 years and older)
Monotherapy with all indicated AEDs should be attempted before initiating combination therapy.

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