Treatment of Oligometastatic Recurrent Endometrial Carcinoma (1–5 Metastases, Up to 3 Regions)
Clinical Scenario
This protocol addresses recurrent endometrial carcinoma presenting in an oligometastatic pattern — defined as between one and five metastases distributed across up to three anatomical regions. This limited disease burden distinguishes this situation from widespread metastatic disease and opens the possibility of aggressive local intervention.
Patient Population
Patients with oligometastatic disease (between one and five metastases in up to three regions) should be considered for local therapy directed at all disease sites.
Treatment Approach — Overview
The primary focus is local treatment targeting the metastatic sites. This may involve surgical or radiotherapy-based strategies, among other local techniques.
Full treatment options, sequencing, and the role of systemic therapy after local treatment are detailed in the complete protocol →
References
- Patients with oligometastatic disease (between one and five metastases in up to three regions) should be considered for local therapy.
- Treatment options include surgery, radical radiotherapy—including stereotactic radiotherapy—and local ablating techniques.
- Following local treatment, systemic therapy could be considered.
DOI: 10.1016/S1470-2045(25)00167-6
View source ↗