Locoregional recurrence of endometrial carcinoma in patients with no prior radiotherapy represents a clinically distinct scenario. Because these patients retain their full radiation tolerance, a broader set of therapeutic options is available compared with previously irradiated patients.
This protocol addresses locoregional recurrent endometrial carcinoma in radiotherapy-naive patients — those who did not receive pelvic or vaginal radiation as part of their primary management.
The preferred primary strategy for locoregional recurrence in this population is radiotherapy-based. Depending on the specific site and nature of the recurrence, this may involve different combinations of radiation modalities, and the addition of systemic therapy may also be considered. The complete structured regimen — including modality selection, technique, sequencing, and combination rules — is available below.
DOI: 10.1016/S1470-2045(25)00167-6