Treatment of Ebola Virus Disease in Seizure

Seizures are a recognised complication of Ebola virus disease (EVD). They can arise from several distinct underlying causes — including hypoglycaemia, sepsis, Ebola viral meningoencephalitis, intracranial haemorrhage, and a pre-existing seizure disorder — making rapid identification of the precipitant clinically important before selecting the appropriate management pathway.

The structured approach involves intravenous anticonvulsant therapy, with agent selection and dosing sequence determined by patient age and clinical context. The protocol specifies primary and alternative agents, age-stratified loading and maintenance regimens, and the decision points between options.

Full details — including agent selection, age-adjusted dosing, sequencing, and clinical decision criteria — are in the structured protocol below.