Seizures can occur in Ebola virus disease for a number of different reasons, including hypoglycaemia, sepsis, Ebola viral meningoencephalitis, intracranial haemorrhage, and underlying seizure disorder, among others. Identifying the contributing cause is an essential part of concurrent management.
The protocol addresses seizure control with intravenous anticonvulsant therapy — agents including phenobarbital and phenytoin are involved, with the choice and parameters structured by patient age group. The full selection criteria, dosing framework, and escalation pathway are detailed in the complete protocol.
Seizures can occur in EVD for a number of different reasons, including hypoglycaemia, sepsis, Ebola viral meningoencephalitis, intracranial haemorrhage and underlying seizure disorder, among others.
17+ years 10 mg/kg. Maximum dose 1 g IV.
12–17 years 20 mg/kg, maximum dose 1 g.
17+ years 20 mg/kg, maximum dose 2 g IV.