Seizure is a serious acute complication in Ebola virus disease. Management must address both immediate seizure control and the underlying cause driving the event, as multiple distinct mechanisms can be responsible.
Seizures in EVD can arise from several concurrent or independent causes — including hypoglycaemia, sepsis, Ebola viral meningoencephalitis, intracranial haemorrhage, and pre-existing seizure disorder, among others. This multifactorial picture shapes each step of the clinical approach.
Immediate measures include supportive positioning, supplemental oxygen, and establishing vascular access. Correction of hypoglycaemia is a priority concurrent step. Pharmacotherapy for acute seizure termination — involving a benzodiazepine-class agent, with route and approach adapted to age and clinical context — is central to the regimen. The complete sequence, agent selection, and further steps are available in the full protocol.