This protocol covers management of Ebola virus disease when bacterial co-infection is present in a neonate. Neonates represent a distinct population: antibiotic selection, dosing intervals, and duration all require age-specific and weight-specific adjustment that differs substantially from older children and adults.
Management centres on combination antibiotic therapy pairing a beta-lactam with an aminoglycoside. Alternative beta-lactam combinations are considered when a specific pathogen, such as Staphylococcus aureus, is clinically suspected. Certain antibiotic classes that are routinely used in older patients carry heightened risk in neonates and are not recommended in this age group.