Ebola virus disease
ICD-10 A98.4 · ICD-11 1D60.0

Hypoglycaemia in Children and Neonates with Ebola Virus Disease

In paediatric patients with Ebola virus disease, low blood glucose — defined as a random glucose below 54 mg/dl (3 mmol/l) — requires prompt intravenous correction. The choice of preparation and the post-bolus maintenance strategy are specific to this population and are detailed in the full protocol below.

Clinical scenario

Children or neonates with confirmed or suspected Ebola virus disease who present with a random blood glucose below 54 mg/dl or below 3 mmol/l. This threshold applies to both adults and children in the context of EVD, and paediatric management follows a distinct approach from adult correction.

Treatment approach (partial overview)

Management uses intravenous glucose correction with a 10% glucose solution (D10). An initial corrective bolus is given slowly, followed by a maintenance dextrose infusion to sustain normalised levels. The specific bolus volume, infusion rate, and repeat-dosing decision are tailored to paediatric physiology — the complete regimen, sequencing, and monitoring protocol are available via the link below.

Clinical target

Blood glucose normalised, confirmed by re-check 15 minutes after corrective treatment.

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References

  1. For paediatric patients, use D10 to treat hypoglycaemia. Do not use D50, which can lead to rebound hypoglycaemia.
  2. Hypoglycaemia is defined as < 3 mmol/l or < 54 mg/dl in adults and children in the context of EVD.
  3. Neonates and children: slow IV push bolus of 2–5 ml/kg of 10% glucose.
  4. After the bolus, maintain dextrose infusion 4–6 mg/kg/min or 5 g/kg/day.
  5. Re-check glucose 15 minutes after correcting.
  6. Repeat dose of 2 ml/kg if glucose remains low and increase dextrose infusion.
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