Treatment of Ebola Virus Disease with Hypoglycaemia and Altered Mentation or Seizure in Adults

This protocol covers adult patients with Ebola virus disease (EVD) who develop symptomatic hypoglycaemia — blood glucose below 54 mg/dl (3 mmol/l) — accompanied by altered mentation or new-onset seizure.

Hypoglycaemia in EVD is defined as a blood glucose below 3 mmol/l or 54 mg/dl. When this finding occurs alongside neurological signs — altered consciousness or seizure — it signals an emergent complication in an already critically ill patient. Rapid identification and correction of the glucose level is a key priority in this setting.

Management begins with emergent intravenous glucose administration to rapidly correct the low blood glucose, followed by a continuous dextrose-containing infusion to sustain correction — with the regimen titrated to maintain blood glucose above the target level.

The complete protocol — including preparation steps, the specific sequence of interventions, and the full monitoring schedule — is accessible via the link below.

Confirmed by re-check 15 minutes after the initial treatment, with continued monitoring until glucose levels stabilise.