Treatment of Severe Pain in Ebola Virus Disease
Severe pain is a recognized clinical challenge in Ebola virus disease, requiring structured analgesic management tailored to each patient.
This first-line protocol addresses severe pain in patients with Ebola virus disease, covering dosing considerations for both adult and paediatric populations and across available routes of administration.
Clinical Approach
Management centres on opioid analgesia with morphine for severe pain, with the preferred route determined by the patient's clinical status. The complete protocol specifies dosing parameters, administration routes, monitoring requirements, and safety thresholds for adults and children — details available via the full regimen below.
References
- Adults: oral dose is 10 mg every 4 hours as needed, maximum dose is 60 mg/day.
- IV dose is 1–4 mg SQ/IV every 4 hours as needed – monitor SBP and RR prior to administration of morphine (hold for low SBP or respiratory rate).
- Children: oral dose is 0.2–0.4 mg/kg/dose every 4 hours.
- IV dose is 0.05–0.1 mg/kg/dose every 4–6 hours as required.
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