Eales disease
ICD-10 H35.0 · ICD-11 9B77

Treatment of Eales Disease with Active Retinal Perivasculitis and Positive Mantoux Test

This protocol addresses the inflammatory stage of Eales disease — specifically, patients presenting with active retinal perivasculitis alongside a positive Mantoux (tuberculin skin) test. This combination of findings defines a distinct sub-population and informs the treatment strategy.

Active perivasculitis in Eales disease with tuberculin reactivity has prompted specific recommendations in the ophthalmic literature. The co-occurrence of a positive Mantoux test alongside active retinal inflammation is a clinically meaningful finding that shapes the therapeutic approach.

Approach: For this scenario, evidence supports a combined strategy involving both an anti-inflammatory agent and anti-tubercular therapy — the full regimen, sequencing, and duration are detailed in the complete protocol.

Full drug selection, dosing schedule, and monitoring guidance available in the structured protocol below.

References
  • In patients with a positive Mantoux test and active perivasculitis, some investigators have recommended treatment with a combination of oral corticosteroids and anti-tubercular therapy.

DOI: 10.1016/s0039-6257(02)00288-6

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