Patients aged 40 years or older presenting with low- or intermediate-grade ductal carcinoma in situ (DCIS) and specific low-risk tumor characteristics represent a distinct clinical subset for which a well-defined management approach exists.
For patients meeting this low-risk profile, the protocol centers on a breast-conserving surgical approach, with specific evidence-based guidance on the role of a post-surgical adjuvant modality — the full protocol details how this is addressed.
DOI: 10.1093/jjco/hyae122
The eligibility criteria in the two trials were almost the same (NG 1, NG 2, tumor diameter <2.5 cm and negative resection margin).
The NCCN guidelines recommend 'omission of radiation' after partial mastectomy for patients with low-risk DCIS, classified as 'Category 2B'.
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