Drug-induced liver injury (DILI) presenting as cholestatic hepatitis with concurrent hypersensitivity features — or arising from antiepileptic drug exposure — represents a clinically distinct pattern that warrants a specific management approach.
This protocol applies to drug-induced cholestatic hepatitis associated with hypersensitivity features such as eosinophilia, rash, and fever, as well as liver injury caused by antiepileptic drugs — a group commonly associated with hypersensitivity presentations.
Management in this setting involves an anti-inflammatory pharmacological intervention. The complete regimen — including agent selection, dosing strategy, and sequencing — is detailed in the full structured protocol.
Full treatment algorithm available via the link below.
DOI: 10.1016/j.jhep.2019.02.014
In addition to ALF, corticosteroids can also be used to treat drug-induced cholestatic hepatitis, in particular in DILI associated with hypersensitivity features such as eosinophilia, rash and fever.
Liver injury caused by antiepileptic drugs are commonly associated with features of hypersensitivity and may respond to steroids.
View source ↗