Treatment of Drug-induced Liver Injury in Adults with Idiosyncratic Acute Liver Failure

Idiosyncratic drug-induced acute liver failure (ALF) in adults is a time-critical presentation requiring prompt evaluation and intervention. When signs of decompensation are present, early action is essential.

Clinical scenario: An adult with idiosyncratic drug-induced acute liver failure presenting with signs of ALF — including encephalopathy and/or coagulopathy (coma grade I–II). Patients with these features should generally be hospitalized for close monitoring and prompt management.

Treatment approach: N-acetylcysteine (NAC) is part of the evidence-based regimen for this presentation — the complete protocol specifies the indication criteria, timing, and full administration details.

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References

DOI: 10.1016/j.jhep.2019.02.014

Adults with idiosyncratic drug-induced ALF should receive NAC early in the course (coma grade I-II).

Patients with signs or biochemical indication of ALF such as encephalopathy and/or coagulopathy should generally be hospitalized.

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