Drug-induced liver injury (DILI) demands prompt recognition and a structured first-line response. Early and correct action on the causative agent is the cornerstone of management, with the goal of achieving full hepatic recovery.
Management begins with targeted action on the drug responsible for liver injury, alongside a structured review of the patient's full medication burden. The complete protocol specifies how to prioritise this process and what steps follow — the approach goes beyond a single action.
When the correct steps are taken promptly, the expected outcome is:
Complete or near-complete resolution of DILI within days to weeksDOI: 10.1016/j.jhep.2019.02.014
The most important initial step in terms of management of suspected DILI is to discontinue the implicated agent.
Stop all non-essential drugs.
There is usually a complete or near complete resolution of DILI within a matter of days to weeks.
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