Moderate DRESS syndrome occupies the middle of the clinical severity spectrum, presenting with findings that exceed mild disease but have not reached the most severe end. Accurate grading of disease severity is the key first step before any treatment decision is made.
Moderate DRESS is characterised by intermediate clinical presentations — a pattern distinct from both mild and severe disease that calls for a specific management approach tailored to this grade.
At this level of severity, management involves transitioning to an oral corticosteroid-based approach. The precise regimen, dosing strategy, and monitoring framework are set out in the full protocol.
DOI: 10.1016/j.annder.2025.103381
Moderate DRESS is characterized by intermediate clinical presentations.
In the event of worsening clinical symptoms and/or laboratory findings, a switch to oral corticosteroid therapy is required.
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