Prolonged Convulsive Seizure in Dravet Syndrome When Benzodiazepines Have Not Worked
This protocol covers the next treatment step for a patient with Dravet syndrome who presents with a prolonged convulsive seizure that has not been controlled by initial benzodiazepine rescue therapy.
Clinical Scenario
Prolonged convulsive seizure in a patient with Dravet syndrome, persisting despite the administration of rescue benzodiazepines.
Previous Line — Goal Not Achieved
Home rescue medication with early use of benzodiazepines was given for the convulsive seizure. The required target — cessation of the convulsive seizure — was not reached. This protocol defines the escalation step that follows.
Next-Line Treatment Approach
The protocol calls for intravenous loading therapy as the next step. The specific agent options, selection criteria, and full clinical regimen are available in the complete protocol below.
Treatment Goal
Cessation of the convulsive seizure.
References
DOI: 10.1111/epi.17274
For prolonged convulsive seizures that persist despite benzodiazepines, either intravenous valproate or levetiracetam should be the next therapeutic choices (Strong).
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