Disseminated nocardiosis is a severe systemic infection. In cases where standard medical therapy has not been adequate, an evidence-based structured protocol defines the next management step.
This protocol incorporates adjunctive interferon-gamma as part of the management approach. The complete regimen — including eligibility, sequencing, and clinical decision points — is detailed in the full structured protocol.
DOI: 10.1093/cid/ciae643
Adjunctive interferon-gamma has been successfully used in a limited number of patients with severe nocardiosis refractory to standard medical therapy, though this treatment remains unproven outside of patients with chronic granulomatous disease.
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