Treatment of Diffuse Large B-Cell Lymphoma with Testicular Involvement
Diffuse large B-cell lymphoma presenting with testicular involvement poses distinct management considerations beyond the primary tumour, due to well-recognised patterns of recurrence at specific sites.
Clinical Scenario
This protocol addresses patients with testicular involvement by diffuse large B-cell lymphoma. In this setting, there is a significant risk of recurrence in the contralateral testicle, as well as a substantial risk of central nervous system (CNS) recurrence — both of which inform the overall treatment approach.
Treatment Approach (Overview)
Management in this scenario includes locoregional radiation directed at the contralateral testicle, alongside systemic CNS prophylaxis — with the complete regimen, sequencing, and additional components detailed in the full protocol.
References
However, there is a significant risk of recurrence in the contralateral testicle and external beam radiation therapy is commonly given to the contralateral testicle.
There is also a substantial risk of central nervous system (CNS) recurrence and CNS prophylaxis is routinely given.
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