Treatment of Cytomegalovirus Retinitis with Zone 1 Involvement: Macula or Optic Nerve
Cytomegalovirus retinitis that involves Zone 1 — the region encompassing the macula or the optic nerve — represents a clinically distinct and high-priority presentation. Disease in this location directly threatens central vision and requires a targeted management approach.
Clinical scenario
Zone 1 involvement means the retinitis has reached the macula or optic nerve. Involvement of these structures results in significant visual impairment, making the anatomical location of disease a key factor in guiding the approach to treatment.
Treatment approach
For Zone 1 disease, management centres on delivering treatment directly within the eye — a localised intraocular approach. The complete protocol specifying the available options and how to select between them is available via the link below.
Full regimen details, route selection, and clinical sequencing are in the structured protocol.
References
DOI: 10.3390/v16091427
- Involvement of the macula or optic nerve (Zone 1) results in significant visual impairment.
- For zone 1 retinitis, intravitreal drug injections or intraocular implants of slow-release GCV reservoirs are considered, with intravitreal injections potentially being more cost-effective.
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