Cystic fibrosis
ICD-10 E84 · ICD-11 CA25

Treatment of Cystic Fibrosis with Unexplained Prolonged Cough Lasting More Than 2 Weeks

Clinical Scenario

This protocol applies to individuals with cystic fibrosis — including those with CRMS/CFSPID — who present with an unexplained prolonged cough lasting more than 2 weeks and in whom no readily identifiable cause has been found.

Treatment Approach

Evidence-based guidance supports considering antibiotic therapy in selected patients presenting with this scenario.

The complete structured regimen — including selection criteria, agent class, and clinical decision points — is available in the full protocol.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1542/peds.2023-064657

The CFF recommends, for people with CRMS/CFSPID and an unexplained prolonged cough (>2 weeks), selectively offering the use of oral antibiotics (Grade C).

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