This protocol applies to patients with cystic fibrosis whose respiratory culture has returned positive for Pseudomonas aeruginosa. The presence of this organism in a respiratory specimen is a clinically significant finding that warrants a specific, evidence-based management decision.
The approach involves selectively offering a targeted antibiotic route of administration — the decision to treat is guided by the positive culture result together with individual patient context. Not all patients meeting this criterion are managed identically; the protocol defines the selection criteria and the specific intervention.
The primary objective is clearance of Pseudomonas aeruginosa from subsequent respiratory cultures, confirmed by follow-up microbiological testing.