Lupus pernio is a form of cutaneous sarcoidosis presenting as potentially disfiguring lesions on the face—particularly on or around the nose, around the eyes, or around the mouth. It is among the most clinically significant skin manifestations of sarcoidosis.
These facial lesions can be mistaken for other dermatological conditions. Lupus pernio represents a specific, recognizable subset of cutaneous sarcoidosis, and its potential for disfigurement makes structured, evidence-based management especially important.
First-line management of lupus pernio in cutaneous sarcoidosis involves a systemic corticosteroid, used at least for the short term. Because of the potential for side effects with prolonged use, the complete protocol addresses further considerations beyond initial therapy—access the full regimen below.
Other specific skin lesions include skin nodules that develop on old scars and tattoos; lesions that look like ulcers; lesions that may be mistaken for psoriasis; and lupus pernio, potentially disfiguring lesions that occur on the face, particularly on or around the nose, around the eyes or mouth.
Systemic corticosteroids are usually used at least for the short term, but because of their many potential side effects, other agents should be considered for longer-term treatment.