Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis or Leishmania peruviana

This protocol applies to patients with cutaneous leishmaniasis in which the causative species is Leishmania braziliensis or Leishmania peruviana — the New World species associated with a distinct set of clinical considerations and treatment pathways.

Clinical scenario: Cutaneous leishmaniasis caused by Leishmania braziliensis or Leishmania peruviana. The applicable treatment approach depends on lesion characteristics, including number, size, location, and whether lymphatic spread is present.

Treatment goal

The primary clinical goal is complete reepithelialization (healing) of the cutaneous lesion.

Treatment approach — partial overview

For qualifying lesions, local treatment options may be appropriate — including certain locally applied agents or physical interventions. The full protocol specifies which lesion characteristics determine eligibility for local versus systemic management, and outlines the available modalities in detail. Full regimen, selection criteria, and sequencing available in the structured protocol below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1111/jtm.12089

Treatment of L. braziliensis, Leishmania peruviana
Single or few lesion(s), not cosmetically disfiguring, lesion with diameter <30 mm, no lymphatic spread, not from Bolivia — local treatment possible
Local infiltration with antimonials +/− cryotherapy
15% Paromomycin/12% methylbenzethonium chloride ointment
Thermotherapy

View source ↗