Treatment of Cryoglobulinemia Type 1 in Multiple Myeloma with Monoclonal IgG Cryoglobulin
Clinical Scenario
This protocol addresses Type I (simple monoclonal) cryoglobulinemia arising in the setting of an underlying plasma-cell malignancy — specifically multiple myeloma — where the circulating cryoglobulin is of the monoclonal IgG class.
Underlying condition: Multiple myeloma.
Monoclonal IgG cryoglobulinemia is a recognised manifestation of myeloma and related plasma-cell dyscrasias. Simple monoclonal (Type I) cryoglobulinemia is associated with B-cell malignancies, notably myeloma and Waldenström macroglobulinemia, as well as MGUS.
Treatment Approach
In myeloma-related cryoglobulinemia, the treatment strategy may include an intensive transplantation-based approach directed at the underlying plasma-cell disease. Full regimen details, sequencing, and eligibility criteria are available in the complete protocol →
References
Monoclonal IgM cryoglobulinemia suggests Waldenström macroglobulinemia or another type of lymphoma and monoclonal IgG cryoglobulinemia myeloma or MGUS.
Simple monoclonal (type I) cryoglobulinemia is associated with B-cell malignancies, notably Waldenström macroglobulinemia and myeloma, and with MGUS.
Autologous bone marrow transplantation may be in order in myeloma-related cryoglobulinemia.
DOI: 10.1016/j.jbspin.2019.01.016
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