What Is the Treatment of Moderate-to-Severely Active Crohn's Disease?
This protocol addresses adult outpatients with moderate-to-severely active Crohn's disease. The primary clinical goals are achieving remission and preventing relapse.
Treatment Approach
Specific immunomodulatory monotherapy options are considered for this population, with distinct evidence-based recommendations depending on whether the goal is inducing or maintaining remission — and explicit guidance on which approaches are advised against.
References
- In adult outpatients with moderate-to-severely active CD, the AGA SUGGESTS using subcutaneous or intramuscular methotrexate monotherapy over no treatment.
- In adult outpatients with moderate-to-severely active CD who have achieved remission, the AGA SUGGESTS using thiopurine monotherapy over no treatment for maintaining remission.
- In adult outpatients with moderate-to-severely active CD, the AGA suggests AGAINST using thiopurines monotherapy over no treatment for inducing remission.
- In adult outpatients with moderate-to-severely active CD, the AGA suggests AGAINST using oral methotrexate monotherapy over no treatment.