This protocol covers a specific and clinically demanding presentation: Crohn's disease in patients who have developed symptomatic intestinal strictures alongside evidence of ongoing active inflammation.
Patients with Crohn's disease who present with symptomatic intestinal strictures and evidence of active inflammation form a distinct sub-population with particular therapeutic considerations. Randomized clinical trial data support the use of advanced therapy in this setting.
Advanced therapy is indicated for this scenario. Evidence from a randomized trial demonstrates that combination treatment approaches can produce meaningful clinical benefit here.
Clinical success is defined by improvement in obstructive symptom burden assessed over a 14-day period, and by radiographic evidence of stricture improvement at 12 months.
DOI: 10.14309/ajg.0000000000003465
Patients with CD with symptomatic strictures and evidence of active inflammation may respond to advanced therapies.
At the end of 12 months, significantly more patients in the high-dose combination therapy arm were more likely to have had an improvement in a 14-day obstructive symptom score (79% vs 64%) and radiographic improvement in stricture (61% vs 28%).
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