Treatment of Cowden Syndrome in Endometrial Cancer

Patients with Cowden syndrome (CS) who develop endometrial cancer represent a clinically distinct population. The characteristics of endometrial cancer in the setting of CS have not yet been fully established, making structured, protocol-guided management especially important.

Clinical scenario

Cowden syndrome diagnosed in a patient with concurrent or diagnosed endometrial cancer. This combination requires a tailored management approach that accounts for the underlying genetic predisposition alongside the oncological priorities of the uterine malignancy.

Treatment approach — partial overview

The foundational intervention is surgical, involving resection of the uterus and bilateral adnexa, with lymph node assessment performed as clinically indicated. Depending on pathological findings and recurrence risk, additional systemic therapy may follow. Full protocol required

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References

DOI: 10.23922/jarc.2023-028

The characteristics of endometrial cancer in patients with CS/PHTS have not been investigated in detail.
In general, the basic treatment for endometrial cancer is surgical resection of the uterus and bilateral adnexa.
Pelvic and para-aortic lymph node dissection is additionally performed, where necessary, including the case with myometrial invasion.
Resected organ tissues are evaluated for residual cancer and the risk of recurrence, and chemotherapy is administered if the risk of recurrence is high.

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