Severe Copper Deficiency in Patients with a History of Bariatric Bypass Surgery

Bariatric bypass surgery substantially alters gastrointestinal anatomy and can impair trace element absorption over time. Severe copper deficiency is a recognised consequence that warrants targeted clinical management.

Clinical scenario: A patient with a history of bariatric bypass surgery presenting with severe copper deficiency. The degree of deficiency in this post-surgical context determines which treatment approach is appropriate.

Treatment approach

For severe copper deficiency following bariatric bypass surgery, a specific method of copper supplementation is preferred — distinct from approaches used in milder cases. The protocol involves an initial phase of supplementation followed by a transition to a different mode of administration.

Full sequencing, dosing, and administration details are available in the complete protocol below.

Treatment goals

With appropriate management, hematologic manifestations are expected to normalize within 12 weeks.

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References

DOI: 10.1002/ncp.10328

In cases of severe deficiency, the IV route is preferred, with 2–4 mg/d during 6 days, followed by enteral administration.

With proper treatment, hematologic manifestations should normalize by 12 weeks, whereas evolution of neurologic symptoms is unclear.

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