What Is the Treatment for Copper Deficiency?

Copper deficiency requires targeted repletion. The clinical approach is individualised: both the route of administration and the specific formulation are selected based on the severity and underlying mechanism of the deficiency.

Treatment Approach

Management centres on copper repletion, with the route — oral or parenteral — determined by the severity and mechanism of the deficiency. Multiple copper salt formulations are available; they differ meaningfully in solubility, which shapes preparation choice in ways the full protocol addresses…

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References

DOI: 10.1002/ncp.10328

The severity and the mechanism of the deficiency will determine the route of administration, ie, an oral or parenteral route.
Copper may be administered as copper sulfate, chloride, or gluconate, but the organic forms (Cu gluconate) are more soluble than inorganic salts.
The proposed upper doses of 10 mg for IV administration comes from reference 9: Internal unpublished data confirm the safety of 10 mg/d.

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