Treatment of Gestational Trophoblastic Neoplasia Following Complete Molar Pregnancy with a FIGO 2000 Score of 6 or Less (Low Risk)
This protocol applies to patients who develop gestational trophoblastic neoplasia (GTN) after a complete hydatidiform mole and whose FIGO 2000 score places them in the low-risk category.
Before starting treatment, women are assessed using the FIGO 2000 scoring system. A total score of 6 or less classifies the patient as low risk and determines the treatment pathway.
Low-risk GTN following complete molar pregnancy is treated with a specific single-agent chemotherapy regimen — the complete schedule, administration details, and continuation criteria are contained in the full protocol.
The primary endpoint is normalisation of the hCG level. Treatment continues beyond that point for a defined further period specified in the full regimen.
Women are assessed before chemotherapy using the FIGO 2000 scoring system (Table 1).
Women with scores of 6 or less are at low risk and are treated with single-agent intramuscular methotrexate, alternating daily with folinic acid for 1 week followed by 6 rest days.
Women with GTN may be treated with single-agent or multi-agent chemotherapy.
Treatment is continued, in all cases, until the hCG level has returned to normal and then for a further 6 consecutive weeks.
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