This protocol addresses patients with established ulcerative colitis in whom a colon polyp has been identified at endoscopy and determined to represent colitis-associated cancer or high-grade dysplasia. The colitis-associated nature of the finding — as opposed to a sporadic lesion — is the key factor that defines the clinical situation and drives the management strategy.
When cancer or high-grade dysplasia is confirmed to be colitis-associated in this setting, current evidence supports a definitive surgical approach.
DOI: 10.1007/s00535-021-01776-1
However, total proctocolectomy is recommended if cancer or high-grade dysplasia is found and determined to be colitis-associated (recommendation strong [agreement rate 100%], level of evidence C).
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