This protocol addresses colon polyp management in patients with familial adenomatous polyposis. FAP encompasses both APC and MUTYH genetic variants, and each subtype carries a high rate of colorectal cancer, making timely and definitive intervention critical.
For patients with FAP, the recommended approach involves a major surgical intervention directed at definitively addressing the colorectal burden of disease. The full structured protocol specifies the procedure, timing considerations, and clinical pathway in detail.
DOI: 10.1007/s00535-021-01776-1
FAP includes both APC and MUTYH variants and there is a high rate of colorectal cancer in each subtype [112–114].
In contrast, total proctocolectomy with ileal-pouch-anal anastomosis is recommended for FAP [118].
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