Treatment of Colon Polyp in Colorectal Neuroendocrine Tumor (NET) ≥10 mm

Colorectal neuroendocrine tumors (NETs) reaching 10 mm or more in size represent a distinct clinical situation requiring specific management decisions. The threshold of 10 mm is meaningful because of the substantially increased risk of regional lymph node spread at this size.

Clinical Scenario

Colorectal NET with a lesion diameter of 10 mm or greater. At this size, the reported incidence of lymph node metastasis rises considerably, which directly informs the choice of intervention and the extent of resection required.

Treatment Approach

The evidence-based approach centres on surgical intervention, with the extent determined by tumour depth and individual patient factors including age, general condition, comorbidities, and personal preferences. The full resection criteria, surgical approach selection, and decision algorithm are available in the complete protocol.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1007/s00535-021-01776-1

In principle, given that the incidence of lymph node metastasis has been reported to increase to 18.7%–30.4% for lesions ≥10 mm in diameter [96–98], surgical resection with lymph node dissection should be performed for lesions of this size.

However, depending on the patient's age, general condition, comorbidities, and personal wishes, complete resection by local excision as a complete excisional biopsy is acceptable if the lesion is confined to T1 (SM).

View source ↗