This protocol addresses Cold agglutinin disease in patients presenting with severe or life-threatening anaemia — a clinical scenario that requires timely, structured management to restore haemoglobin levels and reduce transfusion burden.
The defining feature of this presentation is severe or life-threatening anaemia in the context of Cold agglutinin disease. The depth of anaemia is what establishes the indication for first-line intervention.
Current haematology guidance supports a corticosteroid-based approach when anaemia reaches severe or life-threatening thresholds in Cold agglutinin disease.
The primary targets are an increase in haemoglobin levels and, where achievable, attainment of transfusion independency.