When Clostridioides difficile infection (CDI) occurs during pregnancy, in the peripartum period, or while breastfeeding, treatment selection requires specific consideration for the safety of both patient and child. Standard CDI management does not automatically apply in these reproductive contexts.
This protocol addresses confirmed Clostridioides difficile infection in patients who are pregnant, in the peripartum state, or currently breastfeeding. The presence of these conditions distinguishes this population from the general CDI patient and directs a specific treatment approach.
Management in this population is guided by an oral antibiotic agent recommended for use in pregnant, peripartum, and breastfeeding patients with CDI. The complete regimen, including selection criteria and clinical algorithm, is available in the full structured protocol.
DOI: 10.14309/ajg.0000000000001278