Clinically Non-Functioning Pituitary Adenoma
ICD-10 D35.2 · ICD-11 2F37.0

Treatment of Clinically Non-Functioning Pituitary Adenoma with Significant Growth

Clinically non-functioning pituitary adenomas can enlarge over time. When growth is significant — rapid, occurring over a one- to two-year period, or directed toward the optic chiasm — the clinical situation calls for a defined intervention strategy to prevent visual deficits.

Clinical Scenario

This protocol addresses adenomas that have demonstrated notable growth toward or approaching the optic chiasm. Acting before the tumour abuts the chiasm or produces visual deficits is a key consideration in the management decision.

Treatment Approach

The recommended approach for this scenario involves a surgical intervention. The complete protocol — including referral pathway, procedural specifics, and follow-up considerations — is available in the structured regimen below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1210/jc.2010-1048

Therefore, incidentalomas exhibiting significant growth (which includes growth that is rapid, occurring over a 1- to 2-yr period, and/or that is toward the optic chiasm and if continued could threaten vision in the near future) should be considered for surgery before the incidentaloma progresses to abut the chiasm or produce visual deficits.

These expectations were based on known literature and Task Force members' clinical experience with surgery performed by a surgeon experienced in transsphenoidal pituitary surgery.

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