Clinically non-functioning pituitary adenomas (NFPAs) do not produce a recognised hormonal excess syndrome. When the tumour reaches macroadenoma size, it can compress adjacent optic structures and threaten visual function — a finding that drives the timing and nature of the management decision.
This protocol applies to the macroadenoma presentation of a clinically non-functioning pituitary adenoma — where tumour size brings visual pathways into the picture. Careful surveillance of visual function is central to determining when and how to act.
A surgical approach is the primary intervention considered for this macroadenoma scenario. The full protocol — including patient selection, operative details, and post-operative management — is available via the link below.
The principal clinical objective is normalization or meaningful improvement of visual fields following intervention. Individual outcomes vary, and monitoring continues after treatment.
DOI: 10.1093/ejendo/lvaf091